반응 #46858

반응 방정식

water

4-Fluoro-3-nitro-benzoic acid methyl ester

C-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-yl]-methylamine

triethylamine

→

4-{[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-amino}-3-nitro-benzoic acid methyl ester

용매

DMF

반응 조건

후처리

1. 1
   여과The precipitate was filtered off
2. 2
   세척washed with water
3. 3
   기타The yellow crystalline material was dried under reduced pressure at 40° C.

실험 절차

To a solution of 634.4 mg (3.19 mmol) 4-Fluoro-3-nitro-benzoic acid methyl ester in 12 mL DMF were added 800.0 mg (3.19 mmol) C-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-yl]-methylamine and 0.88 mL (6.37 mmol) triethylamine. The reaction mixture was stirred at room temperature for 16 h. 12 mL water was added. The precipitate was filtered off and washed with water. The yellow crystalline material was dried under reduced pressure at 40° C.

출처