반응 #4684

반응 방정식

4-Cyano-2(R,S)-α-naphthylmethylbutyric acid

2-cyanoethylmalonic acid diethyl ester

sodium hydride

α-chloromethylnaphthalene

→

2-cyanoethyl-α-naphthylmethylmalonic acid diethyl ester

용매

DMF

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGThe mixture is further stirred for 16 hours at 50°
2. 2
   농축concentrated by evaporation
3. 3
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate
4. 4
   세척washed with 0.1N hydrochloric acid and water
5. 5
   건조dried over sodium sulphate
6. 6
   농축concentrated by evaporation

실험 절차

4-Cyano-2(R,S)-α-naphthylmethylbutyric acid: 2.13 g of 2-cyanoethylmalonic acid diethyl ester are added to a suspension of 0.48 g of sodium hydride dispersion in 25 ml of DMF. The reaction mixture is stirred for 2 hours at 80° and then, at room temperature, 1.77 g of α-chloromethylnaphthalene in 5 ml of DMF are added. The mixture is further stirred for 16 hours at 50° and then concentrated by evaporation. The residue is dissolved in ethyl acetate, washed with 0.1N hydrochloric acid and water, dried over sodium sulphate and concentrated by evaporation, leaving 2-cyanoethyl-α-naphthylmethylmalonic acid diethyl ester.

출처