반응 #46805

반응 방정식

1H-Benzoimidazole-2-carboxylic acid

4-(4-Amino-phenyl)-morpholin-3-one

BOP-Cl

NEt3

→

1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

용매

DCM

water

반응 조건

후처리

1. 1
   여과the precipitated product was collected by filtration
2. 2
   기타The crude product was subjected to the next reaction step without further purification

실험 절차

To a solution of 100 mg 1H-Benzoimidazole-2-carboxylic acid and 118 mg 4-(4-Amino-phenyl)-morpholin-3-one in 2 mL DCM, 157 mg BOP-Cl and 0.3 mL NEt3 were added and the mixture was stirred for 16 h at RT. Then, after the reaction mixture was diluted with 20 mL water, the precipitated product was collected by filtration. The crude product was subjected to the next reaction step without further purification. Yield: 122 mg.

출처