반응 #46789

반응 방정식

1H-Benzoimidazole-2-carboxylic acid

1-Pyrimidin-4-yl-piperidin-4-ylamine trifluoroacetate

BOP-Cl

NaHCO3

→

1H-Benzoimidazole-2-carboxylic acid (1-pyrimidin-4-yl-piperidin-4-yl)-amide

용매

DMF

NEt3

반응 조건

후처리

1. 1
   여과the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate
2. 2
   기타After removal of the solvent under reduced pressure the crude product
3. 3
   기타was subjected to the next reaction step without further purification

실험 절차

To a solution of 80 mg 1H-Benzoimidazole-2-carboxylic acid in 1 mL DMF and 0.2 mL NEt3, 200 mg 1-Pyrimidin-4-yl-piperidin-4-ylamine trifluoroacetate and 125 mg BOP-Cl were added and the mixture was stirred for 3 h. Finally, 3 mL saturated NaHCO3 solution were added and the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate. After removal of the solvent under reduced pressure the crude product was subjected to the next reaction step without further purification. Yield: 160 mg.

출처