반응 #46768

반응 방정식

2-bromo-phenethylamine

triethylamine

menthoyl chloride

→

oil

수율 98.3%

2-Isopropyl-5-methyl-cyclohexanecarboylic acid [2-(2-bromo-phenyl)-ethyl]-amide

수율 98.3%

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   기타A 100 mL round bottom flask equipped with a stir bar
2. 2
   세척washed with water (3×100 mL)
3. 3
   건조Organic layer was dried over anhydrous sodium sulfate
4. 4
   농축concentrated under reduced pressure

실험 절차

A 100 mL round bottom flask equipped with a stir bar was charged with CH2Cl2 (30 mL), 2-bromo-phenethylamine (1.0 g, 5.00 mmol) and triethylamine (684 μl, 5.05 mmol). The reaction solution was treated with menthoyl chloride (1.02 g, 5.05 mmol) in one portion and stirred at ambient temperature for 30 minutes. The reaction was diluted with CH2Cl2 (50 mL) and washed with water (3×100 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a thick oil (1.8 g). Product was used for next step without purification.

출처