반응 #46744

반응 방정식

3-Imidazol-1-yl-propylamine

2-Hydroxy-5-methyl-benzaldehyde

Trimethylsilylazide

1-Isocyano-2,2-dimethyl-propane

→

2-[[1-(2,2-Dimethyl-propyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

용매

methanol

반응 조건

후처리

1. 1
   기타After evaporation of the solvent the residue
2. 2
   기타was purified with chromatographic methods

실험 절차

3-Imidazol-1-yl-propylamine (1 mmol) and 2-Hydroxy-5-methyl-benzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Isocyano-2,2-dimethyl-propane (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

출처