반응 #46724

반응 방정식

BBr3

N-(2,4-dimethoxy phenyl)-2,2,2-trifluoro-acetamide

NaHCO3

diethylether

→

desired compound

수율 83.7%

N-(2,4-Dihydroxyphenyl)-2,2,2-trifluoro-acetamide

수율 83.7%

용매

CH2Cl2

반응 조건

후처리

1. 1
   workup.ADDITIONpoured onto H2O (150 mL)
2. 2
   workup.DISSOLUTIONto dissolve any precipitated material
3. 3
   기타The organic layer was Isolated
4. 4
   세척washed with H2O (50 mL)
5. 5
   건조dried (MgSO4)
6. 6
   여과filtered
7. 7
   기타the eluate evaporated to dryness

실험 절차

To a solution of N-(2,4-dimethoxy phenyl)-2,2,2-trifluoro-acetamide (2.50 g; 10 mmol) in CH2Cl2 (20 mL) cooled to −10° C. was added 1 M BBr3 (CH2Cl2; 24 mL; 24 mmol) under N2 atmosphere. The mixture was allowed to warm to room temperature over 2 hours and poured onto H2O (150 mL). Saturated aqueous NaHCO3 (100 mL) and diethylether (100 mL) was added to dissolve any precipitated material. The organic layer was Isolated, washed with H2O (50 mL), dried (MgSO4), filtered and the eluate evaporated to dryness to yield 1.85 g (83%) of the desired compound as a greyish solid.

출처