반응 #46721

반응 방정식

HCl

4-amino-2-methoxy benzoic acid methyl ester

LiOH

→

off-white solid

수율 80.0%

4-Amino-2-methoxy benzoic acid

수율 80.0%

용매

THF H2O

반응 조건

후처리

1. 1
   온도the slurry was refluxed for 3.5 hours
2. 2
   기타the resulting precipitate isolated by filtration
3. 3
   세척washed with H2O (2×15 mL)

실험 절차

To a solution of 4-amino-2-methoxy benzoic acid methyl ester (5 g; 27 mmol) in THF/H2O (125 mL/25 mL) was added LiOH (4.8 g; 200 mmol) and the slurry was refluxed for 3.5 hours. The reaction mixture was neutralized using 4 M HCl (aq) and the resulting precipitate isolated by filtration and washed with H2O (2×15 mL) to give 3.26 g (80%) of an off-white solid. Mp. 144-146° C.

출처