반응 #46695

반응 방정식

2-Aminoindan hydrochloride

1,8-diazabicyclo[5.4.0]undec-7-ene

isopropylsulfonyl chloride

→

oil

수율 164.3%

N-(2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide

수율 164.3%

용매

dichloromethane

반응 조건

후처리

1. 1
   온도cooled
2. 2
   기타The cooling bath was removed
3. 3
   workup.STIRRINGthe mixture stirred at room temperature for 1 h
4. 4
   workup.ADDITIONThe reaction mixture was diluted with dichloromethane (50 ml)
5. 5
   세척washed with 1 M hydrochloric acid (2×50 ml)
6. 6
   기타The organic layer was separated
7. 7
   건조dried over sodium sulphate
8. 8
   기타evaporated under reduced pressure

실험 절차

2-Aminoindan hydrochloride (5.16 g, 30 mmol, Sigma Aldrich Company Ltd.) was suspended in dry dichloromethane (100 ml), and cooled with stirring under argon to 0° C. To the suspension was added 1,8-diazabicyclo[5.4.0]undec-7-ene (14 g, 92 mmol) followed by the dropwise addition of isopropylsulfonyl chloride (8.56 g, 60 mmol). The cooling bath was removed and the mixture stirred at room temperature for 1 h. The reaction mixture was diluted with dichloromethane (50 ml) and washed with 1 M hydrochloric acid (2×50 ml). The organic layer was separated, dried over sodium sulphate and evaporated under reduced pressure to give a yellow oil (11.8 g). The crude product was purified by chromatography on a 50 g Isolute™ Flash silica-gel column eluting from 20-50% ethyl acetate in 40-60° C. petroleum ether to give the title compound as a pale yellow solid (6.88 g, 96%); 1H-NMR (400 MHz, CDCl3) δ 1.39 (6H, d, J=7 Hz), 2.91 (2H, m), 3.18 (1H, m), 3.31 (2H, m), 4.31 (2H, m), 7.21 (4H, m).

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