반응 #4665

반응 방정식

2,5-difluoro-4-aminobenzoic acid

dimethoxytetrahydrofuran

water

→

solid

수율 79.2%

2,5-difluoro-4-(pyrrol-1-yl)benzoic acid

수율 79.2%

용매

acetic acid

반응 조건

후처리

1. 1
   온도The mixture is heated at the boil for 10 minutes
2. 2
   workup.WAITthe resulting mixture is left
3. 3
   온도to cool
4. 4
   기타The precipitate formed
5. 5
   여과is filtered off
6. 6
   세척washed with water

실험 절차

5.2 grams (0.03 mol) of 2,5-difluoro-4-aminobenzoic acid, melting at 250°-3°, are dissolved in 60 ml of glacial acetic acid, and 4 grams (0.03 mol) of dimethoxytetrahydrofuran are added. The mixture is heated at the boil for 10 minutes, 20 ml of water are added and the resulting mixture is left to cool. The precipitate formed is filtered off and washed with water to give 5.3 grams of a solid melting at 196°-8° C.

출처