반응 #4659

반응 방정식

ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate

potassium carbonate

n-propyl bromide

→

solid

수율 70.1%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-propyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

수율 70.1%

용매

water

반응 조건

후처리

1. 1
   온도is heated for 5 hours at 80°-90° C.
2. 2
   workup.WAITleft
3. 3
   온도to cool
4. 4
   기타the precipitate formed
5. 5
   여과is filtered off
6. 6
   세척washed with water
7. 7
   기타recrystallized from ethanol

실험 절차

A mixture of 3 g (0.01 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate, 2.8 g (0.02 mol) of potassium carbonate and 6 g (0.04 mol) of n-propyl bromide is heated for 5 hours at 80°-90° C. and left to cool, water is added and the precipitate formed is filtered off, washed with water and recrystallized from ethanol to give 2.4 g of a solid melting at 128°-130° C.

출처