반응 #46585

반응 방정식

2-Methoxyethylamine

2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

DIEA

→

title compound

수율 90.0%

2-Amino-5-bromo-3-[(2-methoxyethyl)aminomethyl]pyridine

수율 90.0%

용매

CH2Cl2

반응 조건

후처리

1. 1
   농축then was concentrated in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water
3. 3
   추출the solution was extracted with ethyl acetate
4. 4
   세척The combined organic extracts were washed with brine
5. 5
   건조dried over Na2SO4
6. 6
   농축concentrated

실험 절차

2-Methoxyethylamine (1.49 mL, 17.16 mmole) was added to a solution of 2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide (1.49 g, 4.29 mmole) and DIEA (2.24 mL, 12.87 mmole) in CH2Cl2 (10 mL) at RT. The reaction was stirred overnight then was concentrated in vacuo. The residue was diluted with water and the solution was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated to afford the title compound (1.00 g, 90%) as a light brown liquid after drying in vacuo: MS (ES) m/e 260/262 (M+H)+.

출처