반응 #46492

반응 방정식

2-amino-3-(bromomethyl)-5-bromopyridine hydrobromide salt

methylamine

→

title compound

수율 80.0%

2-Amino-5-bromo-3-(methylaminomethyl)pyridine

수율 80.0%

용매

THF

반응 조건

후처리

1. 1
   농축The reaction solution was concentrated
2. 2
   추출extracted with EtOAc (2×100 mL)
3. 3
   세척The combined organic phases were washed with H2O
4. 4
   건조dried over Na2SO4
5. 5
   농축concentrated
6. 6
   기타Purification on silica gel

실험 절차

A solution of the 2-amino-3-(bromomethyl)-5-bromopyridine hydrobromide salt (prepared above) in 40% aqueous methylamine (50 mL) and THF (50 mL) was stirred at RT overnight in a pressure bottle. The reaction solution was concentrated and extracted with EtOAc (2×100 mL). The combined organic phases were washed with H2O, dried over Na2SO4 and concentrated. Purification on silica gel afforded the title compound (4.25 g, 80%) as a yellow oil: MS (ES) m/e 217 (M+H)+.

출처