반응 #46491

반응 방정식

2-amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide

→

title compound

수율 172.4%

2-Amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

수율 172.4%

용매

HBr

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 12 hrs
3. 3
   온도during heating
4. 4
   온도The reaction mixture was cooled
5. 5
   기타a crystalline precipitate formed
6. 6
   여과This was filtered
7. 7
   세척washed with ethyl acetate and air
8. 8
   기타dried

실험 절차

A suspension of 2-amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide (289 g, 1.02 mole) in 48% aqueous HBr (2.9 L) was heated at reflux for 12 hrs. Complete solution occurred during heating. The reaction mixture was cooled and a crystalline precipitate formed. This was filtered and washed with ethyl acetate and air dried to give the title compound (305 g, 86%).

출처