반응 #46458

반응 방정식

2-Bromo-4-methyl-6-iodophenol

cinnamyl bromide

Diisopropylethylamine

→

1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene

수율 101.2%

용매

DMF

반응 조건

후처리

1. 1
   기타The DMF was removed under vacuum, and 1M HCl
2. 2
   workup.ADDITIONwas added until the residue
3. 3
   추출The mixture was extracted with ethyl acetate
4. 4
   건조the combined organic phase was dried over magnesium sulfate
5. 5
   여과filtered
6. 6
   농축concentrated under reduced pressure

실험 절차

2-Bromo-4-methyl-6-iodophenol (7.82 gm, 25 mmol) and cinnamyl bromide (4.93 g, 25 mmol) were added to DMF (20 ml). Diisopropylethylamine (5.3 ml, 30.4 mmol) was added and the mixture heated to 60° C. for 15 minutes and then allowed stir for 16 hours at room temperature. The DMF was removed under vacuum, and 1M HCl was added until the residue was acidic. The mixture was extracted with ethyl acetate, and the combined organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene (10.86 g, 100% yield).

출처