반응 #464319

반응 방정식

3-iodomethyl-4-iodobutyric acid

3-Iodomethyl-4-iodobutyric acid

HCl

ethanol

→

ethyl-3-iodomethyl-4-iodobutyrate

Ethyl-3-iodomethyl-4-iodobutyrate

반응 조건

후처리

1. 1
   기타the solvent is removed under vacuum
2. 2
   workup.DISSOLUTIONthe residue is dissolved in dichloromethane
3. 3
   세척The dichloromethane layer is washed with 10% aqueous sodium bicarbonate (3×100 mL), water (1×100 mL) and brine
4. 4
   건조The separated dichloromethane layer is dried over with magnesium sulfate
5. 5
   여과filtered
6. 6
   기타evaporated

실험 절차

A solution of 2.831 g (8 mmole) 3-iodomethyl-4-iodobutyric acid 17 in 80 mL ethanol is saturated with HCl gas at 0° C. After stirring the solution at room temperature for two days, the solvent is removed under vacuum and the residue is dissolved in dichloromethane. The dichloromethane layer is washed with 10% aqueous sodium bicarbonate (3×100 mL), water (1×100 mL) and brine. The separated dichloromethane layer is dried over with magnesium sulfate, filtered and evaporated to give ethyl-3-iodomethyl-4-iodobutyrate 18.

출처