반응 #46399

반응 방정식

6-amino-5-nitroso-1-benzyl-1,3-dihydropyrimidine-2,4-dione

sodium hydrosulfite

→

5,6-diamino-1-benzyl-1,3-dihydropyrimidine-2,4-dione

용매

ammonia

반응 조건

후처리

1. 1
   온도On cooling the reaction mixture in an ice bath the product
2. 2
   기타precipitated out
3. 3
   여과It was filtered
4. 4
   세척washed with water
5. 5
   기타dried under reduced pressure

실험 절차

To a solution of 6-amino-5-nitroso-1-benzyl-1,3-dihydropyrimidine-2,4-dione (1.15 g, 4.7 mmol) in 12.5% aqueous ammonia (40 ml) at 70° C. was added sodium hydrosulfite (2.44 g, 14 mmol) in portions over 15 minutes. On cooling the reaction mixture in an ice bath the product precipitated out. It was filtered, washed with water, and dried under reduced pressure, to provide 5,6-diamino-1-benzyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (21).

출처