반응 #46378

ord-a4aa2bcb7c574cd0b7948557a8d0a9d0

반응 방정식

CC(C)(C)OC(=O)N1CCCC[C@H]1CN
(S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester
N#Cc1ccnc(Cl)c1
2-chloro-4-cyanopyridine
→
CC(C)(C)OC(=O)N1CCCC[C@H]1CNc1cc(C#N)ccn1
title compound
수율 14.3%
CC(C)(C)OC(=O)N1CCCC[C@H]1CNc1cc(C#N)ccn1
(S)-2-[(4-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester
수율 14.3%

반응물

CC(C)(C)OC(=O)N1CCCC[C@H]1CN
(S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester
N#Cc1ccnc(Cl)c1
2-chloro-4-cyanopyridine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound (0.24 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (1.14 g) and 2-chloro-4-cyanopyridine (0.74 g) according to the method of D28.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07741329B2uspto-grants-2010_06