반응 #463672

반응 방정식

water

sodium methoxide

ethyl formate

2,4,6 trimethylphenylacetonitrile

→

a-formyl-2,4,6-trimethylphenylacetonitrile

용매

benzene

반응 조건

후처리

1. 1
   기타the layers were separated
2. 2
   기타The aqueous layer was separated
3. 3
   추출extracted with ethyl acetate
4. 4
   기타After drying the solvent
5. 5
   기타was removed in vacuo

실험 절차

To a stirred mixture of sodium methoxide (2.78 g, 51 mmol) and ethyl formate (4.0 g, 54 mmol) in 100 mL of benzene was added 2,4,6 trimethylphenylacetonitrile (8.0 g, 50 mmol) over 5 min. After stirring for an additional hour it was treated with water (100 mL) and the layers were separated. The aqueous layer was separated and acidified with 10% HCl and extracted with ethyl acetate. After drying the solvent was removed in vacuo to afford a-formyl-2,4,6-trimethylphenylacetonitrile as colorless crystals melting at 120-122° C.

출처