반응 #463607

반응 방정식

(2-dimethylaminoethyl)sulfamoyl chloride

1,2-O-dioleylglycerol

→

title compound

수율 18.3%

3-O-(2-dimethylaminoethyl)sulfamoyl-1,2-O-dioleylglycerol

수율 18.3%

용매

methylene chloride

methylene chloride pyridine

반응 조건

후처리

1. 1
   기타After completion of the reaction
2. 2
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
3. 3
   workup.ADDITIONthe residue was treated with methylene chloride-saturated aqueous sodium hydrogen carbonate solution
4. 4
   건조The methylene chloride layer was dried over sodium sulfate
5. 5
   농축concentrated under reduced pressure

실험 절차

In 4 ml of methylene chloride-pyridine (2:1) was dissolved 150 mg (0.25 mmol) of 1,2-O-dioleylglycerol. Then, 1 ml of a solution of 150 mg (0.75 mmol) (2-dimethylaminoethyl)sulfamoyl chloride in methylene chloride was added and the reaction was carried out at ambient temperature for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was treated with methylene chloride-saturated aqueous sodium hydrogen carbonate solution. The methylene chloride layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was subjected to column chromatography (silica gel/methylene chloride-methanol) to provide 34 mg (18%) of the title compound of the invention.

출처