반응 #463502

반응 방정식

9-methoxy-5-methyl-2-(2-methylphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline

chloroform

→

title compound

수율 61.6%

9-Methoxy-5-methyl-2-(2-methylphenyl)imidazo[2,1-a]isoquinoline

수율 61.6%

용매

decalin

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 6 hours
2. 2
   온도After being cooled
3. 3
   여과the mixture was filtered
4. 4
   기타the filtrate was evaporated in vacuo
5. 5
   기타The resultant residue was crystallized from a mixture of hexane and ethyl acetate(6:1)

실험 절차

To a solution of 4.9 g of 9-methoxy-5-methyl-2-(2-methylphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline in 30 ml of decalin was added 0.97 g of palladium on activated carbon (Pd 10%) and the mixture was refluxed for 6 hours. After being cooled and an addition of 200 ml of chloroform, the mixture was filtered and the filtrate was evaporated in vacuo. The resultant residue was crystallized from a mixture of hexane and ethyl acetate(6:1) to give 3.0 g of the title compound.

출처