반응 #46328

반응 방정식

Dihexylamine

3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole

→

title intermediate

수율 72.4%

4-(N,N-Di-n-hexylamino)-3-ethoxy-1,1-dioxo-1,2,5-thiadiazole

수율 72.4%

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   기타the residue absorbed onto silica gel
3. 3
   기타and purified by flash column chromatography (silica, hexane:EtOAc 3:1)

실험 절차

Dihexylamine (90 mg, 0.48 mmol) was added to a solution of 3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole (100 mg, 0.48 mmol) in ethanol (5 mL) and the reaction stirred overnight at room temperature. The solvent was removed under reduced pressure and the residue absorbed onto silica gel; and purified by flash column chromatography (silica, hexane:EtOAc 3:1) to yield the title intermediate (120 mg, 72%).

출처