반응 #463208

반응 방정식

potassium hydroxide

tetrafluorophthalic anhydride

4-fluorobenzyl alcohol

→

(4-fluorobenzyloxy) trifluorobenzoic acid

수율 47.0%

용매

water

반응 조건

후처리

1. 1
   추출to the extraction steps

실험 절차

8.4 g (0.15 mol) of potassium hydroxide are dissolved in 30 g of water, and 6.6 g (30mmol) of tetrafluorophthalic anhydride and 30 g (0.238 mol) of 4-fluorobenzyl alcohol are added. The mixture is heated at 100° C. for 12 hours after which the procedure as described in Example 2 is followed. It is advantageous not to allow the pH to fall below 3 prior to the extraction steps. This method gives 4.2 g (14 mmol, corresponding to 47%) of (4-fluorobenzyloxy) trifluorobenzoic acid (purity 80-85%).

출처