반응 #46295

반응 방정식

4-hydroxybutylamine

tert-butyl bromoacetate

→

tert-Butyl[(4-hydroxybutyl)amino]acetate

용매

diethyl ether

diethyl ether

반응 조건

후처리

1. 1
   세척The product mixture was washed successively with aqueous NaHCO3, water, and brine
2. 2
   추출The organic extract
3. 3
   건조was dried over anhydrous sodium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated under vacuum
6. 6
   기타This intermediate was used in the following reaction without further purification

실험 절차

To a cold (0° C.) solution of 4-hydroxybutylamine (9.1 g, 101.8 mmol) in diethyl ether (100 mL), a solution of tert-butyl bromoacetate (7.4 g, 49.3 mmol) in diethyl ether (25 mL) was added dropwise over a period of 2 hours. The reaction mixture was allowed to warm up slowly to room temperature and stirred at the temperature overnight. The product mixture was washed successively with aqueous NaHCO3, water, and brine. The organic extract was dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. This intermediate was used in the following reaction without further purification.

출처