반응 #46246

반응 방정식

4-bromo-benzenesulfonyl chloride

NaHCO3

methylamine

→

4-bromo-N-methyl-benzenesulfonamide

수율 96.8%

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   기타The organic phase was separated
2. 2
   건조dried over Na2SO4
3. 3
   기타Evaporation of the solvent under reduced pressure

실험 절차

To a mixture of sat aq. NaHCO3 (42 g, 0.5 mol), CH2Cl2 (400 mL) and methylamine (51.7 g, 0.5 mol, 30% in methanol) was added a solution of 4-bromo-benzenesulfonyl chloride (127 g, 0.5 mol) in CH2Cl2 (100 mL). The reaction was stirred at 20° C. overnight. The organic phase was separated and dried over Na2SO4. Evaporation of the solvent under reduced pressure provided the 4-bromo-N-methyl-benzenesulfonamide (121 g, crude), which was used in the next step without further purification. 1H NMR (CDCl3, 300 MHz) δ 7.64-7.74 (m, 4H), 4.62-4.78 (m, 1H), 2.65 (d, J=5.4 Hz, 3H).

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