반응 #462176

반응 방정식

compound

N-[3,5-Bis(trifluoromethyl)benzyl]-2-chloro-N-methyl-4-phenyl-3-quinolinecarboxamide

MeNH2 methanol

→

title compound

N-[3,5-Bis(trifluoromethyl)benzyl]-N-methyl-2-methylamino-4-phenyl-3-quinolinecarboxamide

용매

ethanol

반응 조건

후처리

1. 1
   온도with heating
2. 2
   온도under reflux
3. 3
   기타The solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
5. 5
   세척The solution was washed with water
6. 6
   기타dried
7. 7
   기타evaporated

실험 절차

To a solution of the compound obtained in Example 269 (100 mg) in ethanol (4 ml) was added 40% MeNH2 -methanol (12 ml), and the mixture was stirred for 4 hours with heating under reflux. The solvent was evaporated and the residue was dissolved in ethyl acetate. The solution was washed with water, dried and evaporated to yield the title compound as colorless crystals (65 mg).

출처