반응 #46187

반응 방정식

1-(4-methoxy-phenyl)-cyclopropanecarboxylic acid methyl ester

MOMCl

→

1-(3-chloromethyl-4-methoxy-phenyl)-cyclopropanecarboxylic acid methyl ester

수율 102.2%

용매

CS2

반응 조건

후처리

1. 1
   추출The mixture was extracted with CH2Cl2 (150 mL×3)
2. 2
   기타The combined organic extracts were evaporated under vacuum

실험 절차

To a solution of 1-(4-methoxy-phenyl)-cyclopropanecarboxylic acid methyl ester (30.0 g, 146 mmol) and MOMCl (29.1 g, 364 mmol) in CS2 (300 mL) was added TiCl4 (8.30 g, 43.5 mmol) at 5° C. The reaction mixture was heated at 30° C. for 1 day and poured into ice-water. The mixture was extracted with CH2Cl2 (150 mL×3). The combined organic extracts were evaporated under vacuum to give crude 1-(3-chloromethyl-4-methoxy-phenyl)-cyclopropanecarboxylic acid methyl ester (38.0 g), which was used in the next step without further purification.

출처