반응 #46180

반응 방정식

5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole

sodium cyanide

→

(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile

수율 78.6%

용매

dimethylsulfoxide

반응 조건

후처리

1. 1
   workup.ADDITIONThe reaction mixture was poured into ice
2. 2
   추출extracted with ethyl acetate (300 mL)
3. 3
   건조The organic layer was dried over sodium sulfate
4. 4
   기타evaporated to dryness

실험 절차

A mixture of crude 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole (4.4 g) and sodium cyanide (1.36 g, 27.8 mmol) in dimethylsulfoxide (50 mL) was stirred at room temperature overnight. The reaction mixture was poured into ice and extracted with ethyl acetate (300 mL). The organic layer was dried over sodium sulfate and evaporated to dryness to give crude (2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile (3.3 g) which was used directly in the next step.

출처