반응 #46174

반응 방정식

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester

p-toluene sulfonic acid

→

title compound

수율 75.3%

3-phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate methyl ester

수율 75.3%

용매

methanol

반응 조건

후처리

1. 1
   기타The mixture was reacted for 1 hour at 70° C.
2. 2
   세척washed with brine
3. 3
   추출The organic layer was extracted with ethyl acetate
4. 4
   건조dried over anhydrous sulfonate sulfate
5. 5
   농축concentrated
6. 6
   기타the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9)

실험 절차

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester (1.65 g, 4.0 mmol) prepared in (Step 5) of Example 1 was dissolved in methanol (160 ml) and p-toluene sulfonic acid (228 mg, 1.2 mmol) was added thereto. The mixture was reacted for 1 hour at 70° C., and then washed with brine. The organic layer was extracted with ethyl acetate, dried over anhydrous sulfonate sulfate, concentrated, and the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9) to obtain the title compound (yield 75.3%) as a red solid.

출처