반응 #46173

반응 방정식

6-Bromomethyl-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester

Pyridine

morpholine

→

6-(morpholine-4-yl methyl)-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester

수율 16.1%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출the organic layer was extracted with ethyl acetate/ammonium chloride/saturated sodium chloride
2. 2
   건조dried over anhydrous magnesium sulfate
3. 3
   농축concentrated
4. 4
   기타the resulting residue was purified by column chromatography

실험 절차

6-Bromomethyl-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester (1.1 g, 2.96 mmol) was dissolved in N,N-dimethylformamide. Pyridine (264 μl, 3.26 mmol) and morpholine (284 μl, 3.26 mmol) were added thereto and the mixture was stirred for 2 hours. After the reaction was completed, the organic layer was extracted with ethyl acetate/ammonium chloride/saturated sodium chloride, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography to obtain 180 mg of 6-(morpholine-4-yl methyl)-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester (180 mg, yield 16.1%) as red oil.

출처