반응 #46168

반응 방정식

Hydroxy amine

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

hydrochloric acid

pyridine

→

1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile

수율 45.0%

용매

ethanol

반응 조건

후처리

1. 1
   추출The organic layer extracted with ethyl acetate
2. 2
   세척was washed with distilled water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated
5. 5
   기타the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2)

실험 절차

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile (200 mg, 0.547 mmol) was dissolved in ethanol. Hydroxy amine.hydrochloric acid (114 mg, 1.64 mmol) and pyridine (173 mg, 2.18 mmol) were added thereto and the mixture was stirred for 4 hours at 70° C. The organic layer extracted with ethyl acetate was washed with distilled water, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2) to obtain trails 1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile (95 mg, yield 45%) as a red solid,

출처