반응 #46167

반응 방정식

2-Bromo-3-phenyl-6-(3-phenylpropoxy)indene-1-one

Copper (I) cyanide

ammonium chloride

→

title compound

수율 83.3%

1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

수율 83.3%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도The mixture was cooled
2. 2
   추출The organic layer was extracted with ethyl acetate
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated
5. 5
   기타the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3)

실험 절차

2-Bromo-3-phenyl-6-(3-phenylpropoxy)indene-1-one (1.0 g, 2.3 mmol) was dissolved in N,N-dimethylformamide (10 ml). Copper (I) cyanide (617 mg, 6.9 mmol) was added thereto and the mixture was stirred for 3 hours at 150° C. The mixture was cooled, and saturated ammonium chloride was added thereto. The organic layer was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3) to obtain the title compound (700 mg, yield 80%) as a red solid.

출처