반응 #46166

반응 방정식

sodium chloride

N-bromosuccinimide

2,2′-azobisisobutyronitrile

3-Phenyl-6-(3-phenylpropoxy)indene-1-one

→

title compound

수율 60.0%

2-bromo-3-phenyl-6-(3-phenylpropoxy)indane-1-one

수율 60.0%

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   추출extracted with dichloromethane
2. 2
   건조The extract was dried over anhydrous magnesium sulfate
3. 3
   농축concentrated
4. 4
   기타the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:5)

실험 절차

3-Phenyl-6-(3-phenylpropoxy)indene-1-one (200 mg, 0.586 mmol) was dissolved in carbon tetrachloride, and N-bromosuccinimide (313 mg, 1.75 mmol) and 2,2′-azobisisobutyronitrile (9.7 mg) were added thereto. Then, the mixture was refluxed for 1 hour under a 375 W tungsten lamp. After the reaction was completed, saturated sodium chloride was added thereto and extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:5) to obtain title compound (147 mg, yield 60%) as a red solid.

출처