반응 #46157

반응 방정식

Piperonyl alcohol

Triethylamine

thionyl chloride

→

5-chloromethyl benzo[1,3]dioxol

수율 100.0%

용매

benzene

반응 조건

후처리

1. 1
   추출The reaction mixture was extracted with sodium bicarbonate and ethyl acetate
2. 2
   기타the organic layer was separated
3. 3
   건조dried over anhydrous magnesium sulfate

실험 절차

Piperonyl alcohol (10 g, 65.7 mmol) was dissolved in benzene. Triethylamine (11 ml, 78.8 mmol) and thionyl chloride (11 ml, 131.4 mmol) were added dropwise thereto and was stirred for 24 hours at 0° C. The reaction mixture was extracted with sodium bicarbonate and ethyl acetate, the organic layer was separated, and dried over anhydrous magnesium sulfate to obtain 5-chloromethyl benzo[1,3]dioxol (11.2 g, yield 100%).

출처