반응 #461525

반응 방정식

2-acetylcyclohexanone

potassium carbonate

ethyl acrylate

→

title compound

수율 97.0%

2-Acetyl-2-[2-(ethoxycarbonyl)ethyl]cyclohexanone

수율 97.0%

용매

toluene

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타partitioned
3. 3
   workup.DISTILLATIONbetween distilled water (200 ml) and toluene (200 ml)
4. 4
   건조The organic layer was dried over magnesium sulphate
5. 5
   여과filtered
6. 6
   농축concentrated under reduced pressure

실험 절차

To a solution of 2-acetylcyclohexanone (25 g, 0.18 mol), potassium carbonate (29.5 g, 0.21 mol) and benzyltriethylammonium chloride (0.8 g, 0.0035 mol) in toluene (70 ml) was added ethyl acrylate (29 ml, 27 g, 0.27 mol) at room temperature. The mixture was heated at 40° C. for 20 hours, filtered and partitioned between distilled water (200 ml) and toluene (200 ml). The organic layer was dried over magnesium sulphate, filtered and concentrated under reduced pressure to give the title compound as a brown oil, (41.7 g, 97%) .

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