반응 #46139

반응 방정식

4-chlorobutanoyl chloride

3-(2-aminoethyl)-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one hydrochloride

triethylamine

→

titled product

6-Methoxy-2-methyl-3-[2-(2-oxopyrrolidin-1-yl)ethyl]-4-phenylisoquinolin-1(2H)-one

용매

dichloromethane

반응 조건

후처리

1. 1
   농축the mixture was concentrated in vacuo
2. 2
   workup.ADDITIONTetrahydrofuran was added (15 mL)
3. 3
   workup.ADDITIONSodium hydride was added (58 mg, 60% dispersion in mineral oil, 1.45 mmol)
4. 4
   workup.WAITat 50° C. for 2 hours
5. 5
   기타The solution was partitioned between EtOAc and saturated NaHCO3 solution
6. 6
   세척the organic layer was washed with brine
7. 7
   건조dried over Na2SO4
8. 8
   여과filtered
9. 9
   농축concentrated in vacuo
10. 10
    기타The crude residue was purified by preparative reversed phase HPLC

실험 절차

To a solution of 3-(2-aminoethyl)-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one hydrochloride (125 mg, 0.362 mmol) in 15 mL of dichloromethane was added triethylamine (0.202 mL, 1.45 mmol), followed by 4-chlorobutanoyl chloride (0.045 mL, 0.40 mmol). After 45 minutes, the mixture was concentrated in vacuo. Tetrahydrofuran was added (15 mL), and the solution was cooled to 0° C. Sodium hydride was added (58 mg, 60% dispersion in mineral oil, 1.45 mmol). The reaction mixture was stirred at 0° C. for 30 minutes, at room temperature for 16 hours, then at 50° C. for 2 hours. The solution was partitioned between EtOAc and saturated NaHCO3 solution, and the organic layer was washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo. The crude residue was purified by preparative reversed phase HPLC to provide the titled product. Proton NMR for the product was consistent with the titled compound. ESI+MS: 377.27 [M+H]+.

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