반응 #461375

반응 방정식

acetic acid

2-cyanothiophene

sodium methoxide

→

methyl 2-thiophenecarboximidate

용매

methanol

반응 조건

후처리

1. 1
   농축the solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONDiethyl ether (40 ml) was added to the concentrated residue, and insolubles
3. 3
   기타were removed by filtration
4. 4
   농축The filtrate was concentrated under reduced pressure

실험 절차

2-cyanothiophene (5.46 g, 50 mmol) was dissolved in methanol (25 ml), and sodium methoxide (0.27 g, 5 mmol) was added. The mixture was stirred at room temperature for 18 hours. After the reaction was completed, acetic acid (0.33 g, 5.5 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (40 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 2-thiophenecarboximidate (6.35 g) as a yellow oil.

출처