반응 #46116

반응 방정식

2-Chloro-5-nitrobenzenesulphonamide

cyclopropylamine

→

2-cyclopropylamino-5-nitrobenzenesulphonamide

용매

dioxane

반응 조건

후처리

1. 1
   workup.ADDITIONabove is introduced into a hermetically closed vessel
2. 2
   workup.ADDITIONcontaining
3. 3
   기타After this time period, the solvent and the reagent are removed
4. 4
   농축by concentrating under reduced pressure
5. 5
   여과is collected by filtration
6. 6
   세척washed with methanol
7. 7
   기타dried

실험 절차

2-Chloro-5-nitrobenzenesulphonamide (5 g) prepared in the Step above is introduced into a hermetically closed vessel containing a mixture of dioxane (70 mL) and cyclopropylamine (3.5 mL). The hermetically closed vessel is placed in an oven at 100° C. for 24 hours. After this time period, the solvent and the reagent are removed by concentrating under reduced pressure. The residue is taken up in methanol (20 mL) and the insoluble material, which contains the title product, is collected by filtration, washed with methanol and dried.

출처