반응 #46113

반응 방정식

4,5-dichloro-2-fluorobenzenesulphonamide

cyclopropylamine

→

title product

4,5-dichloro-2-cyclopropylaminobenzenesulphonamide

용매

dioxane

반응 조건

후처리

1. 1
   기타The solvent and the excess of amine are removed by distillation under reduced pressure
2. 2
   workup.DISSOLUTIONthe residue is dissolved in methanol (20 mL)
3. 3
   온도The methanolic solution is cooled on an ice bath
4. 4
   workup.ADDITIONwater (60 mL) is added

실험 절차

A solution of 4,5-dichloro-2-fluorobenzenesulphonamide (3 g) in dioxane (30 mL) to which cyclopropylamine (3 mL) has been added is heated at 100-110° C. in a hermetically closed vessel for 24 hours. The solvent and the excess of amine are removed by distillation under reduced pressure and the residue is dissolved in methanol (20 mL). The methanolic solution is cooled on an ice bath, and water (60 mL) is added. The precipitate obtained (the title product) is collected by filtration, washed with water and dried. It is used in the following Step without being otherwise purified.

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