반응 #46080

반응 방정식

HCl

n-butyl lithium

cyclopropylsulfonylamine tert-butyl carbamate

chloromethyl methyl ether

→

1-methoxymethylcyclopropylsulfonylamine tert-butylcarbamate

용매

THF

반응 조건

후처리

1. 1
   온도to warm to room temperature overnight
2. 2
   추출was then extracted with ethyl acetate (4×50 mL portions)
3. 3
   건조The combined extracts were dried (MgSO4)
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

To a solution of cyclopropylsulfonylamine tert-butyl carbamate (1.0 g, 4.5 mmol) dissolved in THF (30 mL) cooled to −78° C., was added n-butyl lithium (6.4 mL, 10.2 mmol, 1.6M in hexane) and the reaction mixture was stirred for 1 hour. To this solution was added a neat solution of chloromethyl methyl ether (0.40 mL, 5.24 mmol), and the mixture was slowly allowed to warm to room temperature overnight. The solution pH was adjusted to 3 using 1N aqueous HCl and was then extracted with ethyl acetate (4×50 mL portions). The combined extracts were dried (MgSO4), filtered, and concentrated to afford 1-methoxymethylcyclopropylsulfonylamine tert-butylcarbamate, as a waxy solid (1.20 g, 100%) which was taken directly into the next reaction without further purification: 1H NMR (CDCl3) δ 1.03 (m, 2H), 1.52 (s, 9H), 1.66 (m, 2H), 3.38 (s, 3H), 3.68 (s, 2H), 7.54 (s, 1H); 13C NMR (CDCl3) δ 11.37, 28.29, 40.38, 58.94, 73.43, 83.61, 149.57.

출처