반응 #46078

반응 방정식

N-tert-Butyl-(1-methyl)cyclopropylsulfonamide

methyl benzoate

→

N-tert-Butyl-(1-benzoyl)cyclopropyl-sulfonamide

수율 66.0%

반응 조건

후처리

1. 1
   기타This compound was obtained in 66% yield
2. 2
   기타The compound was purified by column chromatography over SiO2 using 30% to 100% CH2Cl2 in hexane

실험 절차

This compound was obtained in 66% yield using the procedure described for the synthesis of N-tert-Butyl-(1-methyl)cyclopropylsulfonamide except 1.2 equivalents of methyl benzoate was used as the electrophile. The compound was purified by column chromatography over SiO2 using 30% to 100% CH2Cl2 in hexane: 1H NMR (CDCl3) δ 1.31 (s, 9H), 1.52 (m, 2H), 1.81 (m, 2H), 4.16 (bs, 1H), 7.46 (m, 2H), 7.57 (m, 1H), 8.05 (d, J=8.5 Hz, 2H).

출처