반응 #46029

반응 방정식

hydrochloric acid

propanoyl chloride

3-((4-propylcyclohexyl)cyclohexyl)phenol

water

→

3-((4-propylcyclohexyl)cyclohexyl)phenyl propanoate

수율 109.9%

용매

pyridine

반응 조건

후처리

1. 1
   workup.ADDITIONaddition
2. 2
   추출The aqueous layer was extracted with diethyl ether, which
3. 3
   workup.ADDITIONwas added to the organic layer
4. 4
   세척the organic layer was washed with a saturated salt solution
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off

실험 절차

Under a nitrogen atmosphere, 1.7 g of propanoyl chloride was added to 5.0 g of 3-((4-propylcyclohexyl)cyclohexyl)phenol (3) dissolved in 10 mL of pyridine under cooling with iced water, and after completing dropwise addition, the mixture was stirred at ambient temperature for 2 hours. The resulting solution was added to 20 mL of 3N hydrochloric acid. The aqueous layer was extracted with diethyl ether, which was added to the organic layer, and the organic layer was washed with a saturated salt solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 6.52 g of 3-((4-propylcyclohexyl)cyclohexyl)phenyl propanoate (4).

출처