반응 #46023

반응 방정식

product

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-1-(4-pyridin-4-yl-piperazin-1-yl)-ethanone

BH3-THF

→

1-[2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-4-pyridin-4-yl-piperazine

용매

THF

반응 조건

후처리

1. 1
   온도the reaction was heated
2. 2
   온도to reflux until the reaction
3. 3
   기타The crude product was purified by silica gel chromatography
4. 4
   기타to afford Example 527

실험 절차

The product of Example 522 was taken in 4 ml of THF to which was added 5 eq. of BH3-THF solution and the reaction was heated to reflux until the reaction was complete. The crude product was purified by silica gel chromatography to afford Example 527.

출처