반응 #46014

반응 방정식

EtOAc

4-chloro-3-ethylphenol

1-fluoro-4-nitrobenzene

potassium carbonate

→

4-(4-chloro-3-ethylphenoxy)-1-nitrobenzene

용매

DMF

반응 조건

후처리

1. 1
   온도After cooling to rt
2. 2
   세척washed with H2O (2×50 mL) and brine (50 mL)
3. 3
   건조dried over sodium sulfate
4. 4
   기타The solvent was removed in vacuuo

실험 절차

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-chloro-3-ethylphenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into EtOAc (100 mL), washed with H2O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(4-chloro-3-ethylphenoxy)-1-nitrobenzene. The crude product was used for further transformation.

출처