반응 #459955

반응 방정식

N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester

L-methionine benzyl ester

→

N-t-butoxycarbonyl-L-tryptophyl-L-methionine benzyl ester

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The solvent is then removed by evaporation under reduced pressure

실험 절차

A solution of 26.6 parts N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester and 12.0 parts L-methionine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. The solvent is then removed by evaporation under reduced pressure. The crude dipeptide is then subjected to low-pressure column chromatography on silica gel to afford N-t-butoxycarbonyl-L-tryptophyl-L-methionine benzyl ester.

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