반응 #45930
ord-da35513542f84da8825139e72ef6d024
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The reaction was quenched by cold H2O (50 mL)
- 2추출the resulting mixture was extracted with EtOAc (3×100 mL)
- 3세척The combined EtOAc extracts were washed with brine (3×50 mL)
- 4건조dried (anhydrous Na2SO4)
- 5기타The solvent was removed in vacuo
실험 절차
To a stirred solution of 6-(3-diethylaminopropoxy)-2,4-difluoronitrobenzene (11 mmol) and triethylamine (22 mmol) in DMF (20 mL), a solution of n-butylamine (11 mmol) in DMF (8 mL) was added dropwise at rt, and the mixture was stirred at rt for 10 h. The reaction was quenched by cold H2O (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-6-(3-diethylaminopropoxy)-4-fluoronitrobenzene which was used for further transformation.