반응 #459032

ord-d58bfc5e82ae41a3829b987158d635d0

반응 방정식

C[C@H]1CC(=O)C=C2CC[C@@H]3[C@H](CC[C@]4(C)C(=O)CC[C@@H]34)[C@]21CO
19-hydroxy-1α-methyl-4-androstene-3,17-dione
C[C@@H]1CC2=CC(=O)CC[C@]2(CO)[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12
17β,19-dihydroxy-7α-methyl-4-androstene-3-one
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CC[C@@H]2O
17β, 19-dihydroxy-4-androsten-3-one
→
CC1=C2CC[C@@H]3[C@H](CC[C@]4(C)[C@@H](O)CC[C@@H]34)[C@@]2(CO)CCC1=O
17β,19-dihydroxy-4-methyl-4-androsten-3-one
CC1=C2CC[C@@H]3[C@H](CC[C@]4(C)C(=O)CC[C@@H]34)[C@@]2(CO)[C@@H](C)CC1=O
19-hydroxy-1α,4-dimethyl-4-androstene-3,17-dione

반응물

C[C@H]1CC(=O)C=C2CC[C@@H]3[C@H](CC[C@]4(C)C(=O)CC[C@@H]34)[C@]21CO
19-hydroxy-1α-methyl-4-androstene-3,17-dione
—
17β,19-dihydroxy-6α,17α-dimethyl-4-androsten-3-one
C[C@@H]1CC2=CC(=O)CC[C@]2(CO)[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12
17β,19-dihydroxy-7α-methyl-4-androstene-3-one
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CC[C@@H]2O
17β, 19-dihydroxy-4-androsten-3-one

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Following essentially the same procedure and substituting 17β, 19-dihydroxy-4-androsten-3-one, 19-hydroxy-1α-methyl-4-androstene-3,17-dione and 17β,19-dihydroxy-7α-methyl-4-androstene-3-one for the 17β,19-dihydroxy-6α,17α-dimethyl-4-androsten-3-one above results in the preparation of 17β,19-dihydroxy-4-methyl-4-androsten-3-one, 19-hydroxy-1α,4-dimethyl-4-androstene-3,17-dione, and 17β,19-dihydroxy-4,7α-methyl-4-androsten-3-one, respectively.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04087524uspto-grants-1978_05