반응 #4584

반응 방정식

2-(2-propanon-1-yloxy)phenylsulfonamide

ethylene glycol

p-toluenesulfonic acid

toluene

→

2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도is heated for 7 hours
2. 2
   온도to reflux
3. 3
   기타while simultaneously separating
4. 4
   기타the water of reaction
5. 5
   세척the organic phase is washed with saturated sodium bicarbonate solution and water
6. 6
   기타dried
7. 7
   농축concentrated

실험 절차

A mixture of 4.58 g of 2-(2-propanon-1-yloxy)phenylsulfonamide, 2 ml of ethylene glycol, 0.02 g of p-toluenesulfonic acid and 30 ml of toluene is heated for 7 hours to reflux while simultaneously separating the water of reaction. The cooled solution is taken up in 80 ml of ethyl acetate and the organic phase is washed with saturated sodium bicarbonate solution and water, dried and concentrated, affording 5 g of 2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide in the form of a yellow viscous oil which can be further used without purification.

출처