반응 #45830

반응 방정식

(3S)-3-(Dimethylamino)pyrrolidine

dimethyl sulfoxide

2-amino-5-bromo-4-fluoro-6-methyl-3-nitrobenzonitrile

triethylamine

→

compound

수율 97.5%

2-Amino-5-bromo-4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-6-methyl-3-nitrobenzonitrile

수율 97.5%

용매

water

반응 조건

후처리

1. 1
   기타The reaction liquid
2. 2
   여과the precipitated solid was collected by filtration
3. 3
   세척washed with water
4. 4
   기타dried

실험 절차

(3S)-3-(Dimethylamino)pyrrolidine (140 μl, 1.10 mmol) was added to a dimethyl sulfoxide (2 ml) solution of 2-amino-5-bromo-4-fluoro-6-methyl-3-nitrobenzonitrile (I-266) (274 mg, 1.00 mmol) and triethylamine (209 μl, 1.50 mmol), followed by stirring at room temperature for 30 minutes. The reaction liquid was poured into water, and the precipitated solid was collected by filtration, washed with water, and dried to obtain the entitled compound (359 mg, 97%) as a yellow solid.

출처