반응 #458270

반응 방정식

ethyl chloroformate

4-benzyloxypiperidine hydrochloride

K2CO3

water

→

1-Ethoxycarbonyl-4-benzyloxypiperidine

용매

chloroform

반응 조건

후처리

1. 1
   기타the organic phase is decanted after dilution with 54 ml of chloroform
2. 2
   세척washed 3 times with 20 ml of water
3. 3
   건조dried (MgSO4)
4. 4
   기타Evaporation of the solvent in vacuo
5. 5
   기타gives a liquid, which
6. 6
   workup.DISTILLATIONis distilled in vacuo

실험 절차

3,4 g (0.033 mol) of ethyl chloroformate are added dropwise to a stirred mixture of 6.83 g (0.03 mol) of 4-benzyloxypiperidine hydrochloride, 7.74 g (0.056 mol) of dry K2CO3, 26 ml of water and 26 ml of chloroform. After stirring for 1 hour, the organic phase is decanted after dilution with 54 ml of chloroform, and washed 3 times with 20 ml of water and dried (MgSO4). Evaporation of the solvent in vacuo gives a liquid, which is distilled in vacuo.

출처